Lumateperone and pimavanserin both skip D2 blockade for 5-HT2A activity, but only one expanded to three indications. Here's what to know before prescribing either.

This article and associated images are based on a poster originally authored by Sophie O’Neil, Kyle Thompson, Rita Pereira, Emily Russell and Stuart McElroy and presented at ELRIG Drug Discovery 2025 ...

ALPHA | Overview of Technology◾️What is SciTech at Acadia Pharmaceuticals?Drug discovery technology centered on modulating neurotransmissionAcadia Pharmaceuticals' science and technology focuses on ...

With clozapine's REMS eliminated, the real differentiator among nine D2/5-HT2A antagonist SGAs is metabolic and QTc risk, not access.

Serotonergic psychedelics, such as psilocybin and LSD, are also commonly referred to as hallucinogens because at higher "trip-inducing" doses (as opposed to microdoses), these drugs typically trigger ...

A serotonin-specific receptor can determine how important visual stimuli are perceived. This explains the effects of certain drugs and could help in understanding psychiatric diseases. Signals in our ...

Signals in our brain are not always processed in the same way: Certain receptors modulate these mechanisms, influencing our mood, perception, and behavior in various ways. One of these is the 5-HT2A ...

STUART, Fla.--(BUSINESS WIRE)--Cognigenics, a pioneering company in RNA-based therapeutics for neuropsychiatric conditions and neurocognitive disorders, announced the publication of its latest ...

Jonathan from the Institute of Human Anatomy uses real human brain dissections to show where psychedelic compounds bind and how they alter perception. The video traces oral ingestion (oral cavity → ...

Up to 90% of people with dementia develop at least one behavioral or psychological symptom, such as psychosis, anxiety or agitation/aggression, which often overlap and worsen both patient quality of ...

2A Biosciences Inc. has divulged compounds acting as 5-HT2A and 5-HT2C receptor agonists reported to be useful for the treatment of atopic dermatitis, conjunctivitis, Crohn’s disease, type 2 diabetes, ...